Chematek Research Published in ACS Organic Process Research & Development

Chematek is proud to announce the publication of a significant research paper in *Organic Process Research & Development*, a leading peer-reviewed journal published by the American Chemical Society. The paper presents a comprehensive review of Synhydrid chemically known as Sodium bis(2-methoxyethoxy)aluminium hydride, or SDMA one of Chematek's flagship organometallic reducing agents. This publication marks a major scientific milestone for the company, representing the culmination of years of research into a reagent that Chematek has championed as a safer, more efficient alternative to traditional reducing agents.

The research was conducted in close collaboration with two distinguished academics from the University of Nantes: Professor Jacques Lebreton, who also serves as Chief Scientific Officer at ATLANCHIM PHARMA, and Dr. Arnaud Tessier. This academic-industry partnership brought together Chematek's decades of practical, commercial expertise with the rigorous analytical frameworks of world-class university research. The resulting paper provides a thorough examination of SDMA's chemical behaviour, selectivity, and performance characteristics offering the scientific community a comprehensive reference for one of the most versatile modern reducing agents available.

At its core, the publication addresses a challenge that has long confronted chemists working in pharmaceutical, fine chemical, and advanced synthesis contexts: how to achieve powerful, controlled reduction chemistry without the significant safety risks that come with pyrophoric reagents such as lithium aluminium hydride (LAH) and diisobutylaluminium hydride (DIBAL-H). Synhydrid delivers comparable reactivity while being non-pyrophoric and air-stable, eliminating the risk of spontaneous ignition and dramatically simplifying handling, transport, and large-scale use. The paper outlines these performance advantages with the depth and rigour that peer-reviewed publication demands.

For Chematek, seeing this research in print represents more than a scientific achievement it is a validation of a philosophy the company has held since the 1980s, when it first introduced sodium borohydride to the Italian pharmaceutical sector. The publication reinforces Chematek's position as the global steward of Synhydrid and signals the company's ongoing commitment to advancing reduction chemistry through innovation, collaboration, and evidence-based science. Chematek thanks Professor Lebreton and Dr. Tessier for their partnership in bringing this work to the scientific community.